• Instron 1321 Universal Testing Machine
  • Retrofitted with Instron 8800MT digital controls
• Instron ElectroPuls 3000N All-Electric Tension-Torsion Dynamic Test Instrument
• Full size and mini C-arm, for fluoroscopy
• Two Tekscan systems: one for biomechanical joint studies and a portable system for plantar pressure measurements
• Machine shop equipment to fabricate custom fixtures

Histology Suites (Medical Campus)

• Leica CM1860UV cryostat
• Leica Histology cassette printer
• Leica HistoCore PEARL Automated tissue processor
• Leica HistoCore Arcadia H paraffin tissue embedder with Arcadia C cold plate
• Leica ST4020 stainer
• Leica HI1210 water bath
• ThermoFisher HM355S rotary microtome
• Olympus confocal microscope IX81 with Fluoview 1000
• Olympus IX70 inverted microscope
• Nikon Eclipse E600 Fluorescence microscope
• Nikon Eclipse TS100 Inverted microscope

Paraffin Histological Processing (Main Campus)

• Thermo Scientific HistoStar™ Paraffin Embedding Workstation
• Thermo Scientific Shandon Finesse 325 Microtome
• Thermo Scientific STP 120 Spin Tissue Processor

Plastic Histological Processing and Imaging (Main Campus)

• Buehler Isomet Low Speed Saw and Ecomet 300 Polisher/Grinder for bone plastic dynamic histomorphometry sectioning and polishing
• Zeiss LSM-710 confocal microscope. Fast superesolution of multicolor samples to get 4-8x improvement in signal to noise, 1.7x increase in resolution and increased acquisition at 27 frames per second. Features a wet stage and incubation system for keeping cells in a viable cell culture environment for days.

Frozen Histological processing (Main Campus)

• OCT Embedding Workstation
• Leica CM1860 UV Cryostat

• Luminex 200 flow cytometer
• Luminex INTELLIFLEX-DRSE flow cytometer
• Two BioTek 96- well microplate automatic washers
• Synergy H1M microplate reader
• CTL ImmunoSpot S6 Universal M2 ELISpot Analyzer
• PerkinElmer Thermogravimetric Analyzer 8000 system with IR 2000 infrared spectrometer
• Criterion Western blotting system

Medical Campus

• Lago X in vivo imaging system
  • 2D/3D bioluminescence and 2D fluorescence with x-ray coregistration
• Siemens Inveon PET/CT/SPECT scanner (via BARC)
• Bruker 7T/30 Biospec MRI (via BARC)
• iTheraMedical MSOT inVision optoacoustic imaging platform (via BARC)
• FLIR a655sc thermal imaging camera
• DSI Buxco whole-body plethysmography system with modified automated gas delivery system

Main Campus

• Bruker In Vivo MicroCT System: Maintenance-free 20-100kV micro-focus X-ray source, automatic 6-position filter changer, 11Mp cooled X-ray camera, continuously variable magnification with smallest pixel size of 2.8 micron. Features an animal bed heater, isoflurane port, on-screen dosimeter, and live vitals monitoring during rodent CT scanning.
• Bose 3200: Tabletop, electromagnetic driven materials testing machine capable of loading up to 250N with an extended 150mm max stroke at frequencies of 300Hz. Its axial setup is used for post-mortem 3 point bending of mouse long bones. Can be equipped with a torque rotational motor for fractured femoral torsion testing applications.
• Bose Electroforce 5500: Compact (less than 16kg), electromagnetic driven materials testing machine capable of loading up to 200N with a 13mm max stroke at frequencies of 20Hz. Can be used for in vivo tibial axial compression experiments.
• Aurora 1300A: 3-in-1 Muscle Testing System: The test system allows for in vivo complete muscle testing of the tibialis anterior or gastrocnemius muscle via a dual-lever force/displacement transducer and high power-biphasic electrode stimulator. The platform and limb plates are temperature-controlled designed to support and fix the animal and limb being tested. The system can be converted to an isolated (in vitro) muscle test system with the attachment of an optional 25mL bath.

• Bruker Skyscan 2214 High-Resolution, Multiscale Nanotomograph. This “NanoCT” allows for imaging of structures with true submicron resolution such as soft tissues, bone osteocytes, dentinal tubules, osteointegration of biomaterials and high-density implants, as well as high-resolution characterization of other biological samples.  Its uniquely large field of view allows for the analysis of objects up to 300 mm in size. For objects up to 12 mm in size, it provides better than 500-nanometer true 3D resolution. The achievable voxel size is 60 nanometer. Additionally, it has four different detectors that allow for versatility in imaging a wide variety of samples such as geologic samples, polymers and composites, as well as batteries and fuel cells.

• ThermoFisher ESCALab 250 X-ray photoelectron spectrometer. The ESCALab is multitechnique platform for studying the surface of materials. The instrument is equipped with a 95mm field emission gun for Auger spectroscopy and SEM imaging with a 90nm spatial resolution and a UV photoelectron lamp.

• Scanning electron microscopes and a transmission electron microscope: a Hitachi SU-70 FE-SEM, Zeiss Auriga SEM/FIB, and Zeiss libra 120 TEM. The Hitachi SEM is a field emission unit which allows for a 1nm spatial resolution. The unit also is equipped with a STEM options, a Nabity Lithography System, dedicated backscatter detector, and Genesis EDAX system with low element windows for detection of Be to Pu. The Libra is the Zeiss workhorse microscope which features point to point resolution of 0.34nm. The Zeiss Auriga is a dual beam focused ion beam scanning electron microscope. The instrument features and Genesis EDAX system with low element window and an EBSD detector.

• VEECO ICON atomic force microscope. The ICON features VEECO's latest technology providing AFM with less than a 35pm signal to noise operating in tapping mode. The instrument is capable of operating in multiple modes including lateral force (LFM), magnetic force (MFM), surface potential, scanning capacitance (SCM), Tunneling (TUNA or STM), and conductive (CAFM).

• Zeiss LSM-710 confocal microscope. Fast superesolution of multicolor samples to get 4-8x improvement in signal to noise, 1.7x increase in resolution and increased acquisition at 27 frames per second. Features a wet stage and incubation system for keeping cells in a viable cell culture environment for days.

• Horiba LABRam HR Evolution Confocal Raman Spectrometer. This device provides high spectral resolution performance, multiple gratings with automated switching, and full system automation for Raman and PL with SWIFT™ and DuoScan™ Technologies.

• Buehler Isomet Low Speed Saw and Ecomet 300 Polisher/Grinder for bone plastic dynamic histomorphometry sectioning and polishing